发明名称 |
ANTI-CD40 ANTIBODY MUTANTS |
摘要 |
FIELD: pharmacology. ^ SUBSTANCE: present invention refers to immunology and biotechnology. There are antibody-antagonist to CD40 with their variable areas derived from an antibody produced of hybridoma 4D11 (FERM BP-7758). The constant areas of antibodies are derived from human IgG4 with mutations S228P and L235E. There are described related coding polynucleotides and the based expression vector. There is disclosed host-cell containing said vector. There is described method for preparing monoclonal antibody and application thereof in the pharmaceutical composition. ^ EFFECT: application of the invention provides reduced ADCC and CDC activity that can find application in therapy of autoimmune diseases and graft rejection. ^ 10 cl, 26 dwg, 2 tbl, 22 ex |
申请公布号 |
RU2377254(C2) |
申请公布日期 |
2009.12.27 |
申请号 |
RU20060126979 |
申请日期 |
2004.12.24 |
申请人 |
KIRIN FARMA KABUSIKI KAJSJA |
发明人 |
TAKAKHASI NOBUAKI;MIURA TORU;KITAGAVA JOSINORI;KHIRANO AKI |
分类号 |
A61K39/395;A61P7/00;A61P37/00;C07K16/28;C12N15/13;C12N15/63;C12P21/08 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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