发明名称 |
FILAMENTOUS BACTERIOPHAGE DISPLAYING PROTEIN AS A BINDER OF ANTIBODIES AND IMMUNOCOMPLEXES FOR DELIVERY TO THE BRAIN |
摘要 |
The present invention relates to a phage display vehicle composed of a filamentous bacteriophage displaying on its surface, as a non-filamentous bacteriophage molecule, protein A or a fragment or variant thereof capable of binding the Fc portion of antibodies, and an antibody or an antigen-antibody immunocomplex bound to protein A or a fragment or variant thereof by its Fc portion. The phage display vehicle is formulated into a pharmaceutical composition and can be used to treat/inhibit or to diagnose a brain disease, disorder or condition.
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申请公布号 |
US2009317324(A1) |
申请公布日期 |
2009.12.24 |
申请号 |
US20070279689 |
申请日期 |
2007.02.15 |
申请人 |
RAMOT AT TEL AVIV UNIVERSITY |
发明人 |
SOLOMON BEKA;COHEN KUPIEC RACHEL |
分类号 |
A61K51/10;A61K39/395;A61P25/00;C12N7/00 |
主分类号 |
A61K51/10 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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