| 摘要 |
<P>PROBLEM TO BE SOLVED: To provide a novel compound that inhibits an interaction between an Mdm2 (murine double minute 2) protein and a p53 protein and exhibits antitumor activities. Ž<P>SOLUTION: The imidazothiazole derivative represented by formula (1) bearing various substituent groups inhibits an interaction between the Mdm2 protein and the p53 protein and exhibits antitumor activities. R<SP>1</SP>, R<SP>2</SP>, R<SP>3</SP>, R<SP>4</SP>and R<SP>5</SP>in formula (1) are specifically defined. Ž<P>COPYRIGHT: (C)2010,JPO&INPIT Ž
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