| 发明名称 |
CHIMERIC PROTEINS WITH CELL-TARGETING SPECIFICITY AND APOPTOSIS-INDUCING ACTIVITIES |
| 摘要 |
The present invention relates to chimeric proteins with cell-targeting specificity and apoptosis-inducing activities. In particular, the invention is illustrated by a recombinant chimeric protein between human interleukin-2 (IL2) and Bax. The chimeric protein specifically targets IL2 receptor (IL2R)-expressing cells and induces cell-specific apoptosis.
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| 申请公布号 |
US2009317358(A1) |
申请公布日期 |
2009.12.24 |
| 申请号 |
US20090417277 |
申请日期 |
2009.04.02 |
| 申请人 |
YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREWUNIVERSITY OF JERUSALEM |
发明人 |
YARKONI SHAI;BEN-YEHUDAH AHMI;AZAR YEHUDITH;AQEILAN RAMI ISHAQ;BELOSTOTSKY RUTH;LORBERBOUM-GALSKI HAYA |
| 分类号 |
A61K38/19;A61K38/00;A61K38/16;A61K38/22;A61K38/48;A61K39/395;A61P35/00;C07K14/00;C07K14/47;C07K14/52;C07K14/55;C07K14/575;C07K16/18;C12N9/50 |
主分类号 |
A61K38/19 |
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