| 摘要 |
Disclosed are oxazolidinone compounds of formula (ZP) which are useful in the preparation of antibacterial quinolone compounds of formula (I), wherein U is a CH group; V is an oxygen atom; W is a heterocycloalkylene group containing a ring having 4, 5, 6 or 7 ring atoms, wherein said heterocycloalkylene group is substituted by an OH group and wherein said heterocycloalkylene group is optionally further substituted; X is an oxygen atom; Y is an oxazolidin-2-one moiety attached to the fluorobenzene ring through its nitrogen atom; and Z is an optionally substituted alkylene, alkenylene, alkynylene, heteroalkylene or heteroaralkylene group. Also disclosed are compounds of formula (I) wherein A is a nitrogen atom or a CH group; Z is -(CH2)n-, and W is a 4-6 membered nitrogen containing heterocycloalkylene ring, wherein the group Z-W is substituted by an OH, OPO3H2, OSO3H or a heteroalkyl group carrying at least one OH, NH2, SO-3H, PO3H2 or COOH.
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