| 摘要 |
Disclosed is a process for the production of a hydroxybenzoate salt of (4E)-N-methyl-5-(5-isopropoxy-3- pyridinyl)-4-penten-2-amine (hydroxybenzoate salt of E-metanicotine-type compound). Patients susceptible to or suffering from conditions and disorders, such as central nervous system disorders can be treated by administering to a patient in need thereof compositions comprising the hydroxybenzoate salt of E-metanicotine-type compound. The formation of hydroxybenzoate salts of the E-metanicotine compounds is also useful in purifying the E-metanicotine compounds, as the hydroxybenzoate salts tend to crystallize out, leaving impurities such as Z-metanicotine compounds, and compounds where the double bond has migrated, in solution. If desired, the hydroxybenzoate salts can be converted to either the free base (the E-metanicotine) or to another pharmaceutically acceptable salt form.
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