发明名称 |
Phosphorylation of tau by abl |
摘要 |
Methods of diagnosing a tauopathy and predicting whether a subject will develop a tauopathy are provided. Also provided are antibody preparations that specifically bind to tau phosphorylated at tyr394 and/or tyr310. Methods of inhibiting tau phosphorylation in a cell and methods of treating a subject having a tauopathy are additionally provided. Methods of treating a subject at risk for a tauopathy are also provided. Additionally, non-human mammals comprising a transgene encoding an abl tyrosine kinase are provided. Also provided are methods of evaluating whether a compound inhibits development of a tauopathy.
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申请公布号 |
US2009317406(A1) |
申请公布日期 |
2009.12.24 |
申请号 |
US20090319283 |
申请日期 |
2009.01.05 |
申请人 |
DAVIES PETER;CONRAD CHRISTOPHER |
发明人 |
DAVIES PETER;CONRAD CHRISTOPHER |
分类号 |
A61K39/395;C07K16/18;C12N5/06;C12Q1/02;G01N33/536;G01N33/68 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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