发明名称 CYCLOPROPYL-FUSED PYRROLIDINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME
摘要 <p>Dipeptidyl peptidase IV (DP 4) inhibiting compounds are provided having the formula (I) where x is 0 or 1 and y is 0 or 1 (provided that x = 1 when y = 0 and x = 0 when y = 1); n is 0 or 1; X is H; and wherein R 1 , R 2 , R 3 and R 4 are as described herein. A method is also provided for treating diabetes and related diseases, especially Type II diabetes, and other diseases as set out herein, employing such DP 4 inhibitor or a combination of such DP 4 inhibitor and one or more of another antidiabetic agent such as metformin, glyburide, troglitazone, pioglitazone, rosiglitazone and/or insulin and/or one or more of a hypolipidemic agent and/or anti-obesity and/or other therapeutic agent.</p>
申请公布号 IL151372(A) 申请公布日期 2009.12.24
申请号 IL20020151372 申请日期 2002.08.21
申请人 BRISTOL-MYERS SQUIBB COMPANY 发明人
分类号 C07D401/06;A61K31/403;A61K31/4045;A61K31/454;A61K45/00;A61P1/00;A61P1/04;A61P3/00;A61P3/04;A61P3/06;A61P3/08;A61P3/10;A61P9/10;A61P15/00;A61P19/02;A61P19/10;A61P25/18;A61P31/18;A61P37/02;A61P37/06;A61P43/00;C07C271/12;C07D209/52;C07D403/06 主分类号 C07D401/06
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