发明名称 |
VACCINES AND METHODS FOR PREVENTION AND TREATMENT OF DRUG-RESISTANT HIV-1 AND HEPATITIS B VIRUS |
摘要 |
The present invention provides methods for lowering a viral load of a virus resistant to an antiviral drug by inducing cytotoxic T lymphocytes (CTL) to recognize a predetermined mutated epitope within a viral protein of the drug-resistant virus. CTLs are induced by immunizing a host with a peptide comprising the predetermined mutation. The immunostimulating peptide may be further improved by epitope-enhancement for inducing specific CTLs. The antiviral protection against drug-resistant virus shown by compositions of the present invention and mediated by human HLA-restricted CTL has not been previously achieved.
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申请公布号 |
US2009317418(A1) |
申请公布日期 |
2009.12.24 |
申请号 |
US20060816704 |
申请日期 |
2006.02.22 |
申请人 |
THE GOV'T OF USOA AS REPRESENTED BY THE SECRETARYOF THE DEPT OF HHS |
发明人 |
CATANZARO ANDREW;YARCHOAN ROBERT;BERZOFSKY JAY A.;OKAZAKI TAKAHIRO;SNYDER, II JAMES T.;BRODER SAMUEL |
分类号 |
A61K39/21;A61K39/12;A61K39/29;A61P31/12;A61P31/14;A61P31/18;C07K7/06;C12N5/00;C12N7/06 |
主分类号 |
A61K39/21 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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