发明名称 |
PROCESS FOR RELEASE OF BIOLOGICALLY ACTIVE SPECIES |
摘要 |
A process for the release of a biologically active species comprising the steps of: providing a mesoporous oxide-based material having structural order and at least one level of porosity; fixing or immobilizing said biologically active species in said ordered mesoporous oxide; and providing said ordered mesoporous oxide with said fixed or immobilized biologically active species in vivo thereby realizing intraluminally induced substantially pH-independent supersaturation of said biologically active species resulting in enhanced transepithelial transport; wherein said biologically active species is a poorly soluble therapeutic drug classified as belonging to Class II or Class IV of the Biopharmaceutical Classification System and said ordered mesoporous oxide has a pore size in the range of 4 to 14 nm.
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申请公布号 |
US2009318519(A2) |
申请公布日期 |
2009.12.24 |
申请号 |
US20090361381 |
申请日期 |
2009.01.28 |
申请人 |
KATHOLIEKE UNIVERSITEIT LEUVEN |
发明人 |
AUGUSTIJNS PATRICK;MARTENS JOHAN ADRIAAN;MELLAERTS RANDY;VAN DEN MOOTER GUY |
分类号 |
A61K31/4196;A61K31/41;A61K47/02 |
主分类号 |
A61K31/4196 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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