发明名称 |
CONTROLLED-RELEASE FORMULATIONS, METHOD OF MANUFACTURE, AND USE THEREOF |
摘要 |
The present invention includes a controlled-release composition having a matrix. The matrix contains a pharmaceutically effective amount of an active agent or a pharmaceutically acceptable salt or solvate thereof, an ionic non-gelling matrix polymer, and a pH modifier. The ionic non-gelling matrix polymer is practically insoluble and unswellable at a first aqueous fluid pH and is soluble at a second aqueous fluid pH. The pH modifier is present in an amount to control the release of the active agent from the composition. The controlled-release composition is substantially free of a gelling or swellable excipient and does not contain a functional coating or a lipophilic component. The present invention also provides methods of making and using the controlled-release compositions.
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申请公布号 |
US2009317471(A1) |
申请公布日期 |
2009.12.24 |
申请号 |
US20080330280 |
申请日期 |
2008.12.08 |
申请人 |
NARINGREKAR GANDHA V;ARNOLD KRISTIN A;ERKOBONI DAVID |
发明人 |
NARINGREKAR GANDHA V.;ARNOLD KRISTIN A.;ERKOBONI DAVID |
分类号 |
A61K9/14;A61K9/22;A61K9/52;A61K31/554;A61P43/00 |
主分类号 |
A61K9/14 |
代理机构 |
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主权项 |
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地址 |
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