发明名称 |
COMPOSITIONS FOR MODULATING A KINASE CASCADE AND METHODS OF USE THEREOF |
摘要 |
The invention relates to compositions comprising 2-(5-(4-(2-morpholinoethoxy)phenyl)pyridin-2-yl)-N-benzylacetamide and its mesylate and dihydrochloride salts. The invention provides an efficient process for the synthesis of 2-(5-(4-(2-morpholinoethoxy)phenyl)pyridin-2-yl)-N-benzylacetamide and its mesylate and dihydrochloride salts and methods for modulating one or more components of a kinase cascade using the compositions of the invention. The present invention also provides a novel polymorph of the mesylate salt of 2-(5-(4-(2-morpholinoethoxy)phenyl)pyridin-2-yl)-N-benzylacetamide (Form A), characterized by a unique X-ray diffraction pattern and Differential Scanning Calorimetry profile, as well as a unique crystalline structure.
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申请公布号 |
US2009318450(A1) |
申请公布日期 |
2009.12.24 |
申请号 |
US20090468694 |
申请日期 |
2009.05.19 |
申请人 |
KINEX PHARMACEUTICALS, LLC |
发明人 |
HANGAUER, JR. DAVID G.;PATRA DEBASIS;CODY JEREMY A.;PALMER GRANT J.;ISBESTER PAUL K.;SALSBURY JONATHON |
分类号 |
A61K31/5377;A61P35/00;C07D413/10 |
主分类号 |
A61K31/5377 |
代理机构 |
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