摘要 |
<p>The invention relates to 3-substituted-1 H-pyrrolo[2,3-b]pyridine, and 3-substituted-1 H- pyrrolo[3,2-b]pyridine compounds of the Formula 1: or a pharmaceutically acceptable salt thereof, wherein the constituent variables are as defined herein, compositions comprising the compounds, and methods for making and using the compounds for the treatment of PI3 and mTOR kinase-mediated diseases, e.g. cancer.</p> |
申请人 |
WYETH;TSOU, HWEI-RU;BIRNBERG, GARY, HAROLD;MAC EWAN, GLORIA, JEAN;AYRAL-KALOUSTIAN, SEMIRAMIS;BURSAVICH, MATTHEW, GREGORY;LOMBARDI, SABRINA;ZHANG, NAN;GILBERT, ADAM, MATTHEW;GROSU, GEORGE, THEODORE;BROOIJMANS, NATASJA;NGUYEN, THAI, THEODORE |
发明人 |
TSOU, HWEI-RU;BIRNBERG, GARY, HAROLD;MAC EWAN, GLORIA, JEAN;AYRAL-KALOUSTIAN, SEMIRAMIS;BURSAVICH, MATTHEW, GREGORY;LOMBARDI, SABRINA;ZHANG, NAN;GILBERT, ADAM, MATTHEW;GROSU, GEORGE, THEODORE;BROOIJMANS, NATASJA;NGUYEN, THAI, THEODORE |