| 摘要 |
Disclosed is a melanin-concentrating hormone receptor antagonist which is useful as a pharmaceutical product for central nervous system diseases, cardiovascular diseases and metabolic diseases. A compound represented by formula (I) [wherein R1a and R1b each represents a hydrogen atom or the like; R2 represents a hydrogen atom, a C1-6 alkyl or the like; Ar1 represents a six-membered aromatic carbocyclic group or a six-membered aromatic nitrogen-containing heterocyclic group; Ar2 represents a group obtained by removing two hydrogen atoms from a six-membered aromatic carbocycle, a six-membered aromatic nitrogen-containing heterocycle or the like; Ar3 represents a monocyclic or bicyclic aromatic carbocycle or aromatic heterocycle; and m1, m2, m3 and m4 independently represent 0, 1, 2, 3 or 4, provided that the total of m1 and m2 is not less than 2 but not more than 6 and the total of m3 and m4 is not less than 2 but not more than 6] is disclosed. The compound is useful as a pharmaceutical product for central nervous system diseases, cardiovascular diseases and metabolic diseases. |
