发明名称 |
Method of preparing human NGF Beta protein |
摘要 |
The present invention provides a transgenic rodent, wherein the genome of said rodent comprising the mutant of NGF-² gene, said rodent expressing the mutein of NGF-². The present invention also provides the method for obtaining the transgenic rodent, and the methods of preparing the corresponding mutein of mutant NGF-² gene, and the protein obtained using this method. The present invention provides a new way to produce human NGF, and exploit a new way to investigate the function of Mutant NGF-² and its receptor in the level of whole animal, and to screen and purify the mutant NGF-² of high activity and safety.
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申请公布号 |
EP2135951(A1) |
申请公布日期 |
2009.12.23 |
申请号 |
EP20080715174 |
申请日期 |
2008.03.07 |
申请人 |
STAIDSON (BEIJING) PHARMACEUTICAL CO., LTD |
发明人 |
ZHOU, ZHIWEN;CHEN, HONGBO;ZHANG, HONGSHAN |
分类号 |
C12N15/12;A01K67/027;A61K38/18;A61P25/00;C07K14/48;C12N15/63;C12N15/85;C12N15/89;C12N15/90 |
主分类号 |
C12N15/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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