发明名称 |
CHARACTERIZATION OF N-GLYCAN MIXTURES BY NUCLEAR MAGNETIC RESONANCE |
摘要 |
The present disclosure provides nuclear magnetic resonance (NMR) methods for characterizing mixtures of N-linked glycans. Without limitation, methods of the present disclosure may be useful in characterizing monosaccharide composition, branching, fucosylation, sulfation, phosphorylation, sialylation linkages, presence of impurities and/or efficiency of a labeling procedure (e.g., labeling with a fluorophore such as 2-AB). In certain embodiments, the methods can be used quantitatively. In certain embodiments, the methods can be combined with enzymatic digestion to further characterize glycan mixtures. |
申请公布号 |
EP2135088(A1) |
申请公布日期 |
2009.12.23 |
申请号 |
EP20080745850 |
申请日期 |
2008.04.15 |
申请人 |
MOMENTA PHARMACEUTICALS, INC. |
发明人 |
PARSONS, IAN, CHRISTOPHER;LANSING, JONATHAN;BECCATI, DANIELA;BAILEY, SCOTT;BOSQUES, CARLOS, J. |
分类号 |
G01N33/68 |
主分类号 |
G01N33/68 |
代理机构 |
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代理人 |
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