发明名称 |
PROCESS FOR PRODUCTION OF MIRTAZAPINE |
摘要 |
The invention provides a process for production of mirtazapine as a convenient process for obtaining mirtazapine from a reaction mixture obtained by cyclization of 2-(4-methyl-2-phenylpiperazin-1-yl)pyridine-3-methanol with concentrated sulfuric acid, at high purity and in a form suitable for safe use as a drug. The production process for mirtazapine is characterized in that a reaction mixture obtained by cyclization of 2-(4-methyl-2-phenylpiperazin-1-yl)pyridine-3-methanol with concentrated sulfuric acid is diluted with water, the dilution is alkalinized in the presence of propanol, the mirtazapine is extracted with propanol and the mirtazapine is crystallized from the extract.
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申请公布号 |
EP2135870(A1) |
申请公布日期 |
2009.12.23 |
申请号 |
EP20080722032 |
申请日期 |
2008.03.13 |
申请人 |
SUMITOMO CHEMICAL COMPANY, LIMITED |
发明人 |
MAEDA, CHIHARU;MAEDA, TAKUMA |
分类号 |
C07D471/14 |
主分类号 |
C07D471/14 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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