| 摘要 |
<p>A process for preparing an emulsion or a dispersion comprising crystalline particles of at least one active principal e.g. fluticasone propionate or ibuprofen, comprises contacting a solution of at least one solute in a solvent or solvents e.g. fluticasone propionate in dichloromethane, ibuprofen in dichloromethane or cetyl alcohol, or budesonide in dichloromethane or methanol, in a first flowing stream with a non-solvent e.g. water, saline, Tween (RTM) in a second flowing stream wherein the non-solvent and solvent are not miscible with each other, so as to form an emulsion or a dispersion. The solute is present in a super-saturated solution, and the emulsion or dispersion is subjected to ultrasonic irradiation to mediate crystal nucleation.</p> |
