Process for preparing esters of 2-(6'-methoxy-2'-naphtyl)-propionic acid via rearrangement of new ketals of 2-halo-1-(6'-methoxy-2'-naphtyl)-propan-1-one.

摘要

Process for preparing esters of 2-(6 min -methoxy-2 min -naphtyl)-propionic acid via rearrangement of new ketals of 2-halo-1-(6 min -methoxy-2 min -naphtyl)-propan-1-one in the presence of a Lewis acid. The esters thus obtained are useful as intermediate products for preparing Naproxen. The process involves the preparation of the following new compounds: - ketals of 2-halo-1-( min -methoxy-2 min -naphtyl)-propan-1-one - esters of 2-(5 min -bromo-6 min methoxy-2 min -naphtyl)-propionic acid -1-(5 min -bromo-6 min -methoxy-2 min -naphtyl)-propan-1-one -2-halo-(5 min -bromo-6 min -methoxy-2 min -naphtyl)-propan-1-one