MODELS FOR COMBINATORIAL PERTURBATIONS OF LIVING BIOLOGICAL SYSTEMS
摘要
<p>Techniques for modeling living biological systems include receiving constant values for multiple interaction factors wij. A set of initial state values is received for state variables that indicate relevant properties of a living biological system. Also received is a set of trial values for perturbation variables that indicate factors that might affect one or more of the relevant properties of the biological system. A temporal change in a value for a particular state variable is determined based on a non-linear transformation of a sum of the trial value for the perturbation that affects the particular state added to a sum of all non-zero values for a product of wij and a state variable over all state variables. In some embodiments, measurement-based values are received for a measurable subset of the state variables. Values for the constant interaction factors wij are determined based on the measurement-based values.</p>
申请公布号
WO2009155009(A1)
申请公布日期
2009.12.23
申请号
WO2009US45353
申请日期
2009.05.27
申请人
MEMORIAL SLOAN KETTERING CANCER CENTER;SANDER, CHRIS;NELANDER, SVEN;WANG, WEI QING;GENNEMARK, PETER;NILSSON, BJORN