发明名称 |
COMPOSITIONS AND METHODS OF USE OF ORF 554 FROM BETA HEMOLYTIC STREPTOCOCCAL STRAINS |
摘要 |
The present invention relates to compositions and methods of use comprising peptidyl-prolyl isomerase (PPI) polypeptides of group C and G streptococci and polynucleotides encoding same. The invention also relates to immunogenic compositions comprising the PPI polypeptides and polynucleotides, as well as antibodies and antibody fragments that bind the PPI polypeptides. In addition, the invention relates to methods of inducing an immune response in a subject against beta hemolytic streptococci using the immunogenic compositions, as well as conferring passive immunity by administering a therapeutic antibody or antibody fragment.
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申请公布号 |
CA2728258(A1) |
申请公布日期 |
2009.12.23 |
申请号 |
CA20092728258 |
申请日期 |
2009.06.19 |
申请人 |
WYETH LLC |
发明人 |
MURPHY, ELLEN;BRAUNSTEIN, EMILY;ANDERSON, ANNALIESA SYBIL;DODGE, INGRID LEA |
分类号 |
A61K39/09;A61P31/04;C07K14/315 |
主分类号 |
A61K39/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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