TARGETED OLIGONUCLEOTIDE COMPOSITIONS FOR MODIFYING GENE EXPRESSION

摘要

The invention comprises compositions and methods for modifying gene expression. Modified oligos of the invention restore the lost function of let- 7 wild type miRNA molecules that are prevented from silencing target genes by mutations occurring within their binding sites. Administration of a particular modified oligo (SEQ ID NO: 22) leads to increased cell death in cancer cells carrying the LCS6 SNP.