INHIBITORS OF VEGF RECEPTOR AND HGF RECEPTOR SIGNALING

摘要

The invention relates to compounds of formula A, and their use for inhibiting the VEGF receptor KDR and the HGF receptor c-met Pn preferred structures of formula A, A1 is S, A2=A3=CH, Z is O, S, S(O)0-2 or NR5, Ar is phenyl, and G includes a nitrogen linker to Ar The groups D, G, and R5 are as defined herein The invention also provides compositions and methods for treating cell proliferative diseases and conditions Examples of the diseases include breast cancer, lung cancer, colon cancer, rectal cancer, bladder cancer, leukemia and renal