CRIPTO-1 AS A BIOMARKER FOR CARDIAC HYPOXIA

摘要

The invention provides use of a probe that binds to Cripto-1 or mRNA encoding Cripto-1, wherein the probe and sample are brought into contact, and wherein detection of overexpression of Cripto-1 by the probe indicates cardiac hypoxia in the sample. The invention also provides a method for detecting cardiac hypoxia in a mammal comprising detecting overexpression of Cripto-1 in the mammal, wherein overexpression of Cripto-1 is indicative of cardiac hypoxia, and a method of monitoring stem cell activity in damaged myocardial tissue of a mammal comprising monitoring Cripto-1 expression in the mammal, wherein increased expression of Cripto-1 is indicative of increased stem cell activity, as well as related kits and arrays.