发明名称 |
SECRETION OF ANTIBODIES WITHOUT SIGNAL PEPTIDES FROM BACTERIA |
摘要 |
<p>The present invention is directed generally to compositions and methods for obtaining secretion of antibodies or antigen-binding antibody fragments from prokaryotes without the need for a signal peptide through making use of mutant host strains with altered secretory properties. In particular, the invention provides host cells and methods for obtaining secretion of antibodies or antigen-binding antibody fragments from bacteria without the need for a signal peptide and provides diverse libraries of antibody sequence resulting from such methods. The invention additionally provides diverse libraries.</p> |
申请公布号 |
EP1907610(A4) |
申请公布日期 |
2009.12.23 |
申请号 |
EP20060786474 |
申请日期 |
2006.07.07 |
申请人 |
KALOBIOS PHARMACEUTICALS, INC. |
发明人 |
YARRANTON, GEOFFREY;BEBBINGTON, CHRISTOPHER, R. |
分类号 |
C12Q1/70;A61K39/395;C12N7/00;C12N15/00;C12P21/04;C12P21/06;C12P21/08 |
主分类号 |
C12Q1/70 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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