| 摘要 |
Carboxtyril derivs. I were prepd. by reaction o II with III (R1=H, C1˜C6 alkyl, C2˜C4 alkyl, C1˜C4 alkylene, phenylalkyl; R2=H, C1˜C4 alkyl, phenyl,; R3=H, OH, C1˜C4 alkyl C1˜C4 alkanoyloxy, 3, 4, C1˜C4 alkyl 5-trimethoxybenzoyloxy; R4=H, C1˜C4 alkly; R6=H, OH, C1˜C4 alkyl; X=halo n=0˜2; Q=2˜3l, m=0˜6,l+m<=6; R13=halo, C1˜C4 alkyl, alkoxy C3˜C8 cyclo alkyl; DM E=-NH2, IV). Thus, 2g 5-[2-hydroxy-3-(4-phenypipe-razinyl)propoxy -3,4-dihydrocarbostyril in 30mL acetone was mixed with 12mL acetyl chloride and heated for 10 hrs. The resulting filtrate ws treated with chloroform to give. 0.5g 5-[2-acetyloxy-3-(4-phenyl piperazinyl) propoxy -3, 4-dihydro-carbostyril. |
