发明名称 |
THERAPEUTIC MONOCLONAL ANTIBODIES THAT NEUTRALIZE BOTULINUM NEUROTOXINS |
摘要 |
This invention provides antibodies that specifically bind to and typically neutralize botulinum neurotoxins (e.g., BoNT/A, BoNT/B, BoNT/E, etc.) and the epitopes bound by those antibodies. The antibodies and derivatives thereof and/or other antibodies that specifically bind to the neutralizing epitopes provided herein can be used to neutralize botulinum neurotoxin and are therefore also useful in the treatment of botulism. |
申请公布号 |
EP2134749(A2) |
申请公布日期 |
2009.12.23 |
申请号 |
EP20080826274 |
申请日期 |
2008.03.21 |
申请人 |
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA |
发明人 |
MARKS, JAMES D.;GEREN, ISIN, N.;GARCIA, MARIA CONSUELO;LOU, JIANLONG;RAZAI, ALI |
分类号 |
C07K16/12;A61K39/40 |
主分类号 |
C07K16/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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