MICROFLUIDIC PLATFORMS FOR GENOTYPING

摘要

The present invention provides for a method and apparatus useful for prospective clinical pharmacogenetic testing and polymorphism genotyping of patients, in particular, analysis of thiopurine s-methyltransferase gene (TPMT) in the patient. The present invention provides exemplified methods for a microchip based Restriction Fragment Length Polymorphism (RPLP) and Allele-Specific PCR (AS-PCR) tests, achpted to a microfluidic chip-based pHR and capillary electrophoresis platform to genotype the common *2, *3A, and *3C functional alleles.