| 发明名称 |
UN PROCEDIMIENTO PARA LA PREPARACION DE RUPATADINA Y SUS SALES. |
| 摘要 |
<p>Rupatadine is synthesized by phase transfer catalysed N-alkylation of Desloratadine in biphasic solvent system using aqueous alkali by reaction of a compound of formula (I), with Desloratadine at temperature up to 500C , wherein solvent selected is water immiscible organic solvent. Rupatadine is further converted to Rupatadine fumarate by reaction of Rupatadine in ketonic solvent with an alcoholic solution of fumaric acid.</p> |
| 申请公布号 |
ES2311426(B1) |
申请公布日期 |
2009.12.22 |
| 申请号 |
ES20070050036 |
申请日期 |
2006.04.22 |
| 申请人 |
CADILA PHARMACEUTICALS LIMITED;CADILLA PHARMACEUTICALS LIMITED |
发明人 |
MAFATLAL KHAMAR BAKULESH;AMBALAL MODI INDRAVADAN;CHANDRAKANT SHUKLA MANISH;KASHYAPBHAI PARIKH KRUNAL;PRABHAKAR DANGE SURYABHAN;RAVI PONNIAH |
| 分类号 |
C07D401/14;A61K31/4545 |
主分类号 |
C07D401/14 |
| 代理机构 |
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