| 发明名称 |
Anti-hepatitis a virus antibodies |
| 摘要 |
Chimpanzee monoclonal antibodies and antigen binding fragments including a gamma1-chain CDR3 region that bind hepatitis A virus (HAV) antigen are disclosed herein. The antibodies neutralize HAV. Also disclosed are methods for using these antibodies and antigen binding fragments in the detection of hepatitis A virus, the inhibition of infection of a subject with hepatitis A virus, and in screening for agents that affect HAV.
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| 申请公布号 |
US7635476(B2) |
申请公布日期 |
2009.12.22 |
| 申请号 |
US20070789377 |
申请日期 |
2007.04.23 |
| 申请人 |
THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES |
发明人 |
SCHOFIELD DARREN J.;EMERSON SUZANNE U.;PURCELL, II ROBERT |
| 分类号 |
A61K39/395;C07K16/00;C07K16/10;C12N5/08;C12N15/00;C12P21/06;C12P21/08;G01N33/53 |
主分类号 |
A61K39/395 |
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