PROCESS FOR THE PREPARATION OF EPSILON -ALKOXYCARBONYLLYSINES AND THEIR ANALOGUES

摘要

A process for the preparation of omega-alkoxycarbonylamino-alpha-aminoacids and alpha,omega orthogonally diprotected diaminoacids from alpha,omega-diaminoacids using 1-alkoxycarbonylbenzotriazoles as protecting agents is disclosed. In an alternative embodiment, carbamoylating agents in the presence of benzotriazoles are used instead of 1-alkoxycarbonylbenzotriazoles. This reaction is preferably applied to the preparation of epsilon-alkoxycarbonyllysines from lysine. A process for the preparation of t-butoxycarbonylbenzotriazoles and novel complexes of omega-alkoxycarbonylamino-alpha-aminoacids with benzotriazoles are also disclosed.