| 摘要 |
PROBLEM TO BE SOLVED: To provide a combinational immunological composition and vaccine about Neisseria meningitidis B and C, and to provide a method of guiding an immunological response by administering the same. SOLUTION: The invention relates to a combination vaccine about Neisseria meningitidis comprising outer membrane proteins from serogroup B and oligosaccharides from serogroup C, and its use for the prevention or treatment of disease. In one aspect, the invention relates to an immunogenic composition or vaccine including NmC oligosaccharides conjugated with a carrier proteins, NmB outer membrane proteins, and a carrier. In a preferred embodiment, the carrier protein is CRM<SB>197</SB>or nontoxic diphtheria toxin, the NmB outer membrane proteins is present as a proteoliposome vesicle, and the carrier is aluminum hydroxide or MF59. COPYRIGHT: (C)2010,JPO&INPIT |
