发明名称 |
COMBINATION OF SPACITABINE (CNDAC) AND DNA METHYLTRANSFERASE INHIBITORS SUCH AS DECITABINE AND PROCAINE |
摘要 |
<p>A first aspect of the invention relates to a combination comprising a DNA methyltransferase inhibitor and 1-(2-C-cyano-2-dioxy-ß-D-arabino-pentofuranosyl)-N4- palmitoyl cytosine, or a metabolite thereof. A second aspect of the invention relates to a pharmaceutical product comprising a DNA methyltransferase inhibitor and 1-(2-C-cyano-2-dioxy-ß-D-arabino- pentofuranosyl)-N4-palmitoyl cytosine, or a metabolite thereof, as a combined preparation for simultaneous, sequential or separate use in therapy. A third aspect of the invention relates to a method of treating a proliferative disorder, said method comprising simultaneously, sequentially or separately administering a DNA methyltransferase inhibitor and 1-(2-C-cyano-2-dioxy-ß-D-arabino- pentofuranosyl)-N4-palmitoyl cytosine, or a metabolite thereof, to a subject.</p> |
申请公布号 |
WO2009150405(A1) |
申请公布日期 |
2009.12.17 |
申请号 |
WO2009GB01418 |
申请日期 |
2009.06.05 |
申请人 |
CYCLACEL LIMITED;GREEN, SIMON, RICHARD;MACKAY, RUTH;FLEMING, IAN, NEIL |
发明人 |
GREEN, SIMON, RICHARD;MACKAY, RUTH;FLEMING, IAN, NEIL |
分类号 |
A61K31/245;A61K31/353;A61K31/502;A61K31/706;A61K31/7068;A61K45/06;A61P35/00 |
主分类号 |
A61K31/245 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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