发明名称 DEGRADED AGONIST ANTIBODY
摘要 The invention relates to a modified antibody which contains two or more H chain V regions and two or more L chain V regions of monoclonal antibody and can transduce a signal into cells by crosslinking a cell surface molecule(s) to thereby serve as an agonist. The modified antibody can be used as a signal transduction agonist and, therefore, useful as a preventive and/or remedy for various diseases such as cancer, inflammation, hormone disorders and blood diseases.
申请公布号 US2009311718(A1) 申请公布日期 2009.12.17
申请号 US20090497131 申请日期 2009.07.02
申请人 CHUGAI SEIYAKU KABUSHIKI KAISHA 发明人 FUKUSHIMA NAOSHI;TSUCHIYA MASAYUKI;UNO SHINSUKE;OHTOMO TOSHIHIKO;YABUTA NAOHIRO;TSUNOD HIROYUKI
分类号 G01N33/53;A61K38/00;C07H21/04;C07K16/18;C07K16/24;C07K16/28;C07K16/30;C12N1/00;C12N5/06;C12N5/10;C12P21/08 主分类号 G01N33/53
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