METHOD FOR PRODUCING SULFOXIDE COMPOUND

摘要

<P>PROBLEM TO BE SOLVED: To provide a method for rapidly producing rabeprazole in good yield. Ž<P>SOLUTION: To provide a method for producing the rabeprazole includes reacting a sulfide compound represented by formula (II) with a hydroxide or alkoxide of an alkali metal, and a hypo-halogenic acid salt in a homogeneous solvent containing water and a water-miscible organic solvent under a condition of pH 13-14. The high-purity rabeprazole can be obtained by crystallizing rabeprazole by using a solvent containing an amine or ammonia when crystallizing the rabeprazole from a mixture containing the rabeprazole. Ž<P>COPYRIGHT: (C)2010,JPO&INPIT Ž