发明名称 |
COMPLEMENT INHIBITORY AGENTS AS THERAPEUTICS IN POSTTRAUMATIC AND DEGENERATIVE ARTHRITIS |
摘要 |
<p>The present disclosure is directed to methods and compositions for treating osteoarthritis and preventing osteoarthritis, by administering a compound that modulates one or more components in the complement system. In one embodiment, a compound that inhibits a component in the complement system is administered to prevent, delay the progression of, or treat osteoarthritis. In other embodiments, compounds with specific inhibition of a component in a particular pathway in the complement system, such as the alternative, mannose binding lectin, and/or classical pathway, are administered to a subject having osteoarthritis or at risk of developing osteoarthritis.</p> |
申请公布号 |
WO2009151634(A1) |
申请公布日期 |
2009.12.17 |
申请号 |
WO2009US03539 |
申请日期 |
2009.06.11 |
申请人 |
THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY;ROBINSON, WILLIAM, H.;HOLERS, V., MICHAEL;ROZELLE, ANDREW, L. |
发明人 |
ROBINSON, WILLIAM, H.;HOLERS, V., MICHAEL;ROZELLE, ANDREW, L. |
分类号 |
A61K38/17;A61K39/395;A61P19/02 |
主分类号 |
A61K38/17 |
代理机构 |
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主权项 |
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地址 |
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