发明名称 |
METHODS AND COMPOSITIONS FOR MODULATING ANGIOGENESIS AND PERICYTE COMPOSITION |
摘要 |
In certain aspects, the present disclosure relates to the insight that a polypeptide comprising a ligand-binding portion of the extracellular domain of activin-like kinase I (ALK1) polypeptide may be used to inhibit angiogenesis in vivo, particularly in mammals suffering angiogenesis-related disorders. Additionally, the disclosure demonstrates that inhibitors of ALK1 may be used to increase pericyte coverage in vascularized tissues, including tumors and the retina. The disclosure also identifies ligands for ALK1 and demonstrates that such ligands have pro-angiogenic activity, and describes antibodies that inhibit receptor-ligand interaction.
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申请公布号 |
US2009311272(A1) |
申请公布日期 |
2009.12.17 |
申请号 |
US20090434598 |
申请日期 |
2009.05.01 |
申请人 |
GRINBERG ASYA;KNOPF JOHN;KUMAR RAVINDRA;PEARSALL ROBERT S;SEEHRA JASBIR;PIETRAS KRISTIAN |
发明人 |
GRINBERG ASYA;KNOPF JOHN;KUMAR RAVINDRA;PEARSALL ROBERT S.;SEEHRA JASBIR;PIETRAS KRISTIAN |
分类号 |
A61K39/395;A61P35/00;C07K16/30 |
主分类号 |
A61K39/395 |
代理机构 |
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地址 |
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