OLIGOPEPTIDE FOR ENHANCING OSTEOINTEGRATION AND OSTEOGENESIS

摘要

The present invention relates to an oligopeptide for enhancing osteointegration and osteogenesis. More specifically, it relates to bioactive oligopeptide compounds having the general structural formula (C or K)-(I, K or P)-(I, P or K)-(K or P)-(K, P or S)-(P or S)-(A or S)-(A, P or S)-(A, P or T)-(E, P or T)-(E, L or T)-(E, L or S)-(A, L or S)-(A, I or S)-(A, I or S)-(I, M or S)-(L, M or S)-(C, L or M). The oligopeptide of the present invention is effective in bone filler replacement, vertical treatment and horizontal treatment. By using this invention, the continuous action of the oligopeptide on the surface of an implant treated with a thin film of the same can reduce the time of initial osteointegration. Additionally, an increase in the success rate of surgical operations on osteopenia patients can be achieved by inducing an increase in osteoblasts and function. It is also possible to achieve bone formation when bone mass is insufficient, without bone replacement, leading to a reduction in surgical operation costs.