发明名称 |
PROCESS FOR PRODUCTION OF ANTIOXIDANT ACTIVE SUBSTANCE |
摘要 |
<p>Disclosed is a process for producing carnosic acid (the major antioxidant active substance contained in a rosemary plant) with high efficiency by carrying out the ortho-position oxidation of a phenol with an oxidizing agent (e.g., 2-iodoxybenzoic acid) and the subsequent ester removal reaction by using, as a starting material, pisiferic acid (the main component of Chamaecyparis pisifera which is a plant which has been planted in great numbers as wood resources). Specifically disclosed is a process for producing an antioxidant active substance contained in a rosemary plant and represented by general formula (5). The process is characterized by comprising: a first step of oxidizing a pisiferic acid derivative represented by general formula (1) with an oxidizing agent represented by general formula (2) or (4); and a second step of reducing or hydrolyzing a pisiferic acid derivative intermediate produced in the first step.</p> |
申请公布号 |
WO2009151057(A1) |
申请公布日期 |
2009.12.17 |
申请号 |
WO2009JP60547 |
申请日期 |
2009.06.09 |
申请人 |
NATIONAL UNIVERSITY CORPORATION TOKYO UNIVERSITY OF AGRICULTURE AND TECHNOLOGY;TADA MASAHIRO |
发明人 |
TADA MASAHIRO |
分类号 |
C07C51/367;A61K31/192;A61K31/366;A61P3/10;A61P17/10;A61P25/28;C07C62/32;C09K15/08 |
主分类号 |
C07C51/367 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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