| 摘要 |
Disclosed is an excellent prophylactic and/or therapeutic agent for diabetic neuropathy, which comprises a 2-[(substituted-indene-7-yloxy)methyl]morpholine represented by the formula (I) or a pharmaceutically acceptable salt thereof as an active ingredient. The prophylactic and/or therapeutic agent is particularly useful as a prophylactic and/or therapeutic agent for diabetic motor nerve disorder (e.g., decrease in muscular strength (decrease in muscular strength to an extent of being unable to independently walk)), diabetic sensory nerve disorder (paresthetic (abnormal vibratory sensation), allodynia, reduced sensation (numbness in limbs, psychroesthesia) or pain), or diabetic autonomic nerve disorder (e.g., abnormal bowel habituation such as constipation and diarrhea, urinary dysfunction, impotence, orthostatic hypotension, dyshidrosis, abnormal heart rate variability, delayed gastric emptying). Also disclosed is an ameliorating gent for a disease condition of diabetic nerve disorder.
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