摘要 |
An industrial process for production of high-purity optically active amine derivatives in high yield while inhibiting the formation of by-products, which comprises subjecting (E)-2-(1,6,7,8-tetrahydro-2H-indeno[5,4-b]furan-8-ylidene)ethylamine to asymmetric reduction, catalytically reducing the obtained product at a reaction temperature of 40 to 100°C and a pH of 3 to 9, subjecting the obtained (S)-2-(1,6,7,8-tetrahydro-2H-indeno[5,4-b]furan-8-yl)ethylamine to propionylation, and then crystallizing the reaction mixture. |
申请人 |
TAKEDA PHARMACEUTICAL COMPANY LIMITED |
发明人 |
URAYAMA, SHINICHI;MUTOU, EIGO;INAGAKI, ATSUSHI;OKADA, TAKASHI;SUGISAKI, SHIGEHARU |