STYRYLBENZOFURAN DERIVATIVES AS INHIBITORS FOR BETA-AMYLOID FIBRIL FORMATION, AND PREPARATION METHOD THEREOF

摘要

PURPOSE: A pharmaceutical composition containing styrylbenzofuran compound is provided to ensure suppression efficiency of beta amyloid fibril formation. CONSTITUTION: A styrylbenzofuran compound is denoted by chemical formula 1. A compound of chemical formula 1 is obtained through Honer-Emmons reaction of a compound of chemical formula 2 with a compound of chemical formula 3 and alkali under the presence of organic solvent. The alkali is hydride of alkali metal, alkyl alkali metal compound, alkoxide compound of alkali metal or alkali metal amide compound. The organic solvent is ether organic solvent. A product thorugh Honer-Emmons reaction is demethylated using boron trichloride, boron trifluoride, boron tribromide or iodotrimethylsilane.