| 摘要 |
<p>Methods for diagnosing a patient as having or being predisposed to developing Lupus are described. The methods comprise detecting in a sample taken from a patient one or more auto- antibodies that bind to auto-antigens, wherein the presence of one or more auto-antibodies, or an increase in the concentration of one or more antibodies, indicates that the patient suffers from or is predisposed to develop Lupus. A total of 31 separate autoantigens are claimed. Methods of monitoring the progression of Lupus or the efficacy of a therapeutic agent to Lupus by detecting the presence of these autoantigens are also claimed, along with diagonistic kits, and the uses of the autoantigens in a vaccine for the treatment of Lupus.</p> |
