FORMATION OF TRIPLE HELIXES OF DOUBLE-STRANDED DNA USING NUCLEOSIDE OLIGOMERS

摘要

A specific segment of double stranded DNA may be detected or recognized by formation of a triple helix structure using an oligomer comprised of nucleosidyl units linked by internucleosidyl phosphorus linkages. Function or expression of double stranded DNA segments may be prevented by triple helix formation. Novel oligomers comprising modified nucleosidyl units are useful in triple helix formation, and may be optionally derivatized with DNA modifying groups.