PHARMACEUTICAL COMPOSITION

摘要

The present invention provides a pharmaceutical composition comprising a combination of an Hsp 90 family protein inhibitor and at least one compound, the said pharmaceutical composition wherein the Hsp 90 family protein inhibitor is a benozoyl compound represented by formula (I):
[wherein n represents an integer of 1 to 5;
R 1 represents substituted or unsubstituted lower alkyl, CONR 7 R 8 (wherein R 7 and R 8 , which may be the same or different, each represent a hydrogen atom, substituted or unsubstituted lower alkyl, or the like), or the like;
R 2 represents substituted or unsubstituted aryl, or the like;
R 3 and R 5 , which may be the same or different, each represent a hydrogen atom, substituted or unsubstituted lower alkyl, or the like;
R 4 represents a hydrogen atom, hydroxy or halogen; and
R 6 represents a hydrogen atom, halogen, substituted or unsubstituted lower alkyl, or the like], or a prodrug thereof; or a pharmaceutically acceptable salt thereof, and the like.