VERFAHREN ZUR MODULATION DER ENTWICKLUNG EINES DURCH EINE NUKLEINSÄURESEQUENZ KODIERTEN POLYPEPTIDS

摘要

A method for modulating the ability of a gene to mutate by analyzing codon usage within the gene and selecting a synonymous nucleotide sequence with a higher, lower or different capacity to mutate. The method permits widening and optimization of the evolutionary landscape of a protein. A computer-implemented method for analyzing and selecting nucleotide sequences with an altered ability to mutate.