AVERMECTIN DERIVATIVES WITH A SPACER INSERTED BETWEEN THE DISACCHARIDE AND THE AGLYCONE USEFUL AS ANTIPARASITIC AGENTS

摘要

There are disclosed avermectin derivatives which incorporate a spacer between the disaccharide and the aglycone. The synthetic spacer-containing analogs are derived from the corresponding aglycones which in turn are prepared by chemical modification of naturally occurring avermectins. The compounds are active antiparasitic agents and compositions for that use are disclosed.