发明名称 |
Hybridization chain reaction |
摘要 |
The present invention relates to the use of nucleic acid probes to identify analytes in a sample. In the preferred embodiments, metastable nucleic acid monomers are provided that associate in the presence of an initiator nucleic acid. Upon exposure to the initiator, the monomers self-assemble in a hybridization chain reaction. The initiator nucleic acid may be, for example, a portion of an analyte to be detected or may be part of an initiation trigger such that it is made available in the presence of a target analyte.
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申请公布号 |
US7632641(B2) |
申请公布日期 |
2009.12.15 |
申请号 |
US20050087937 |
申请日期 |
2005.03.22 |
申请人 |
CALIFORNIA INSTITUTE OF TECHNOLOGY |
发明人 |
DIRKS ROBERT;PIERCE NILES A. |
分类号 |
C12Q1/66;C07H21/02;C12Q1/68 |
主分类号 |
C12Q1/66 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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