| 发明名称 |
PROPANOIC ACID DERIVATIVES THAT INHIBIT THE BINDING OF INTEGRINS TO THEIR RECEPTORS |
| 摘要 |
A method for the inhibition of the binding of .alpha.4.beta.1 integrin to it s receptors, for example VCAM-1 (vascular cell adhesion molecule-1) and fibronectin; compounds that inhibit this binding; pharmaceutically activ e compositions comprising such compounds; and the use of such compounds either as above, or in formulations for the control or prevention of diseases states in which .alpha.4.beta.1 is involved.
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| 申请公布号 |
CA2373180(C) |
申请公布日期 |
2009.12.15 |
| 申请号 |
CA20002373180 |
申请日期 |
2000.05.05 |
| 申请人 |
TEXAS BIOTECHNOLOGY CORPORATION |
发明人 |
KASSIR, JAMAL M.;LI, WEN;BIEDIGER, RONALD J.;SCOTT, IAN L.;MARKET, ROBERT V.;WU, CHENGDE;HOLLAND, GEORGE W. |
| 分类号 |
C07D213/64;C07D229/00;A61K31/192;A61K31/33;A61K31/4166;A61K31/4184;A61K31/4412;A61K31/443;A61K31/465;A61K31/497;A61K31/498;A61K31/501;A61K31/505;A61K31/517;A61P1/04;A61P3/10;A61P7/00;A61P9/10;A61P11/06;A61P17/00;A61P19/02;A61P25/00;A61P29/00;A61P37/06;C07D213/30;C07D215/02;C07D235/04;C07D239/36;C07D317/60;C07D405/12;C07D409/14 |
主分类号 |
C07D213/64 |
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