| 发明名称 |
Universal carrier for targeting molecules to Gb3 receptor expressing cells |
| 摘要 |
The present invention concerns an universal polypeptidic carrier for targeting directly or indirectly a molecule to Gb3 receptor expressing cells and having the following formula STxB-Z(n)-Cys, wherein: STxB is the Shiga Toxin B subunit or a functional equivalent thereof, Z is an amino-acid devoided of sulfydryl group, n being 0, 1 or a polypeptide, Cys is the amino-acid Cysteine, and the use thereof for MHC class I and MHC class II presentation of antigens.
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| 申请公布号 |
US7632514(B2) |
申请公布日期 |
2009.12.15 |
| 申请号 |
US20030628415 |
申请日期 |
2003.07.29 |
| 申请人 |
INSTITUTE CURIE;CENTRE NATIONAL DE LA RECHERCHE SCIENTIFQUE;INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE;UNIVERSITE PIERRE ET MARIE CURIE (PARIS VI) |
发明人 |
JOHANNES LUDGER;TARTOUR ERIC;GOUD BRUNO;FRIDMAN WOLF HERVE |
| 分类号 |
A61K39/38;C12N15/00;A61K38/00;A61K38/16;A61K39/00;A61K39/02;A61K39/385;A61K47/48;A61K48/00;A61P35/00;A61P43/00;C07K1/16;C07K2/00;C07K4/00;C07K5/00;C07K7/00;C07K14/00;C07K14/25;C07K16/00;C07K17/00;C07K19/00;C12N1/21;C12N15/31;C12P21/00;C12Q1/68 |
主分类号 |
A61K39/38 |
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